Pathology Thesis/Dissertation Topics for MD/DNB.​

Updated for the 2026–27 MD Pathology and DNB batch. Click "Protocol →" next to any topic to generate a ready protocol for your thesis submission.

1. A clinical, endoscopic and histomorphological evaluation of esophageal lesions.
2. A clinical, cytological, histomorphological evaluation of lymph nodes in children.
3. Histopathological analysis of prostatic lesions and the assessment of prognosis with immunohistochemistry.
4. A clinicopathological correlation and analysis of ovarian tumours with study of expression pattern of pankeratin.
5. The value of AgNOR study in radiotherapy treated squamous cell carcinoma of the cervix as a diagnostic and prognostic marker.
6. A clinical histomorphological and immunohistochemical analysis of breast neoplasms.
7. A clinical and histomorphological analysis of paediatric malignant neoplasms.
8. Histopathological analysis of central nervous system neoplasms.
9. Helicobacter pylori related gastritis in adults: a clinical, endoscopic and histopathological study.
10. Fine needle aspiration cytology and histopathological correlation of nodular lesion of thyroid with immunohistochemical study.
11. Histopathological analysis of prostatic lesions and role of p63 versus high molecular weight cytokeratin in distinguishing prostatic adenocarcinoma from benign mimics.
12. Histopathological analysis and p53 expression in intestinal tumors.
13. Clinicopathological analysis of ovarian tumors and the role of p53 and Ki-67 in surface epithelial tumors of ovary.
14. Histopathological analysis and Ki-67 expression in various central nervous system tumors.
15. Role of mucin histochemistry and immunohistochemistry in gastric adenocarcinoma.
16. Correlation of ER, PR and HER2/neu with histological variants of breast carcinoma.
17. Anaemia in nonhaematological malignancies: a descriptive study.
18. Mycotic lesions in surgical pathology.
19. The role of Pap smear in detection of cytological abnormalities of uterine cervix in HIV infected women.
20. Haematological profile in the differential diagnosis of microcytic hypochromic anaemia in children.
21. A study of distribution of p53, cyclin D1 and CD44 in oral squamous cell carcinoma.
22. Histopathological spectrum of ovarian tumors: a descriptive study.
23. A study of trucut biopsies of hepatic lesions with special reference to immunohistochemistry and special stain.
24. Study of silver staining of nucleolar organiser regions in malignancies of uterine cervix.
25. A correlative study on bone marrow angiogenesis with bone marrow fibrosis and splenomegaly.
26. Expression of Bcl-2 and Ki-67 in endometrial lesions.
27. The expression and diagnostic utility of AMACR and p63 in prostatic lesions.
28. Cytological grading of ductal carcinoma of breast in fine needle aspirates and its correlation with histological grading.
29. Diagnostic utility of squash cytology and its correlation with histopathology in neuropathological specimen.
30. Placental pathology in low birth weight live births.
31. Utility of RBC histograms in various types of anaemia in pediatric age group (1–18 years).
32. Prevalence of anemia in geriatric population.
33. Comparison of digital vs manual assessment of Ki-67 in breast carcinoma patients: a hospital-based study.
34. Detection of human papilloma virus infection in cases of oral carcinoma using p16 immunohistochemistry.
35. The distribution of mast cells in uterine leiomyoma: a hospital-based observational study.
36. Prevalence of congenital anomalies in fetuses subjected to autopsy: a hospital-based cross-sectional study.
37. Prevalence of thrombocytopenia in pregnancy: a hospital-based study.
38. Correlation of blood parameters with outcome in COVID-19 positive patients.
39. Estimating prevalence of SOX-2 expression in cervical squamous carcinomas: a hospital-based cross-sectional study.
40. Correlation of FNAC and histopathology in the diagnosis of head and neck lesions.
41. Assessment of coagulation parameters in COVID-19 patients: a cross-sectional study.
42. Hematological and biochemical profile of children below 5 years of age, suspected with hemolytic anemia: a hospital-based observational study.
43. A comparative study of hematological and inflammatory markers in preterm labour and term labour.
44. A study of morphological abnormalities in placenta associated with fetal death and stillbirth: a hospital-based observational study.
45. Conventional Papanicolaou (PAP) stain vs rehydrated air dried Pap stain (RADPS) vs rapid economical acetic acid Pap stain (REAP) on vaginal smears: an observational study.
46. Study of Ki-67 expression in oral and oropharyngeal squamous cell carcinoma.
47. Comparative study of peripheral smear with RBC indices and RBC histograms in cases of anemia in adults.
48. Evaluation of CD10 biomarker expression in diagnosis of colorectal carcinoma: a one-year cross-sectional study.
49. Evaluation of derived indices of peripheral whole blood cell counts in non-dialysis CKD patients: a one-year cross-sectional study in a tertiary care hospital.
50. Histopathological spectrum of upper gastrointestinal tract lesions in patients undergoing upper gastrointestinal endoscopic biopsies.
51. Expression of vimentin as a marker of epithelial-mesenchymal transition in invasive breast carcinoma: a hospital-based study.
52. Ki-67 as a diagnostic indicator in differentiating psoriasis from psoriasiform dermatitis: a hospital-based study.
53. Study of dermal vascular changes in psoriasis: an observational study.
54. Evaluation of haematological and biochemical parameters in chronic liver disease patients.
55. Comparison of the neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in schizophrenic patients with healthy individuals: a cross-sectional study.
56. Clinical and diagnostic markers in patients with pregnancy induced hypertension: a hospital-based observational study.
57. Diagnostic utility of cell block method versus conventional smear study in pleural and peritoneal fluid cytology.
58. Evaluation of role of GATA3 expression in differentiating urothelial carcinomas from adenocarcinomas of prostate.
59. The role of p-STAT3 in cervical intraepithelial neoplasia and squamous cell carcinoma.
60. Diagnostic utility of TROP-2 expression in benign and malignant lesions of thyroid.
61. Evaluation of expression of immunohistochemical (IHC) markers high molecular weight cytokeratin (HMWCK) and alpha-methylacyl CoA racemase (AMACR) in prostatic needle biopsies and transurethral resection of prostate (TURP) specimens: a one-year observational study.
62. Histopathological evaluation to compare the diagnostic accuracy of Pipelle endometrial sampling with conventional D&C in patients with AUB.
63. Histopathological study and immunohistochemical expression of EGFR in lung tumours.
64. Study of immunohistochemical expression of AKT (protein kinase B) in prostatic adenocarcinoma: a descriptive study.
65. To study CD64 expression on neutrophil by flow cytometry as novel biomarker in early diagnosis of sepsis (as compared to ESR, CRP and blood culture).
66. Ki-67 expression in endometrial hyperplasia and endometrial carcinoma: an observational study.
67. Identification of lymphatic invasion in breast carcinoma patients using immunomarker D2-40: a one-year cross-sectional study.
68. Evaluation of immunohistochemical expression of COX-2 in breast carcinoma patients: a hospital-based study.
69. Immunohistochemical expression of p16INK4a in patients with squamous cell carcinoma of the cervix: a one-year retrospective and prospective study in a tertiary care hospital.
70. To correlate immunohistochemistry of BRCA1 and BRCA2 in breast carcinoma: a cross-sectional study.
71. Expression of prostate specific membrane antigen in breast cancer patients attending a tertiary care hospital: a one-year cross-sectional study.
72. Role of clinicohaematological profile in diagnosis of dengue: a one-year hospital-based observational study.
73. Comparison of fluorescent staining and conventional staining of skin biopsy in diagnosis of leprosy: a hospital-based study.
74. A comparative study to know the haematological profile and biochemical profile among children with severe acute malnutrition and healthy children.
75. Comparison of efficacy of p63 and smooth muscle myosin heavy chain immunomarkers in distinguishing invasive and non-invasive breast lesions: a one-year observational study.
76. Comparative evaluation of bone marrow aspiration and bone marrow trephine biopsy in hematological conditions: a hospital-based study.
77. Evaluation of risk factors of thrombotic and thromboembolic events among patients with beta thalassemia major: a hospital-based study.
78. Histopathological study of lesions in nasal cavity, nasopharynx and paranasal sinuses: a one-year hospital-based study.
79. Histomorphometrical study of placenta in pre-eclampsia: a hospital-based study.
80. Correlation between donor characteristics and platelet yield during plateletpheresis: a hospital-based study.
81. Effectiveness of bleach method in detection of tuberculosis in lymph node aspirates in comparison to Ziehl–Neelsen method.
82. Expression of androgen receptor in carcinoma breast: a hospital-based study.
83. Histopathological evaluation of spectrum of non-neoplastic lesions in skin biopsies at a tertiary care hospital: a one-year cross-sectional study.
84. Comparison of blood vessel morphometry in normal endometrium and in cases of abnormal uterine bleeding in a tertiary care hospital: an observational study.
85. Study of expression of PTEN (phosphatase and tensin homolog) protein biomarker in renal cell carcinoma: a cross-sectional study.
86. Detection of human papilloma virus type 16 infection in squamous cell carcinoma of cervix using immunohistochemistry: a cross-sectional study.
87. Frequency of overexpression of HER2/neu in colorectal adenocarcinomas: a hospital-based cross-sectional study.
88. A cross-sectional study of p53 expression in patients with squamous cell carcinoma cervix: a hospital-based study.
89. Expression of E-cadherin in breast carcinoma: a hospital-based study.
90. Expression of alpha methyl acyl coenzyme A racemase and its correlation with histopathological prognostic factors in prostate neoplasm: a cross-sectional study.
91. Assessment of megakaryocytic alterations in bone marrow aspiration and biopsy of patients with thrombocytopenia: a hospital-based study.
92. A study of clinico-hematological profile of patients with bicytopenia attending a tertiary care hospital.
93. A clinicopathological study of breast lesions: a hospital-based study.
94. Comparison of efficacy of filter paper cyanmethemoglobin method with automated hematology analyzer for estimation of hemoglobin among patients attending a tertiary care centre.
95. A cross-sectional study to determine glycaemic status among transfusion dependent beta-thalassemia major patients attending a tertiary care hospital.
96. Evaluation of variation in platelet indices among patients with diabetes mellitus attending a tertiary care hospital: a one-year cross-sectional study.
97. Comparison of prevalence of micronuclei in oral exfoliated cells among the users and non-users of tobacco: a one-year study at a tertiary care hospital.
98. Apoptosis and mitotic activity in malignancies: a cross-sectional study.